Accurate prediction of the in vivo biopharmaceutical performance of oral drug formulations is
critical to efficient drug development. Traditionally, in vitro evaluation of oral drug …

Dissolution research started to develop about 100 years ago as a field of physical chemistry
and since then important progress has been made. However, explicit interest in drug related …

The first step in the digestion process is mastication, or chewing, when food is broken down,
lubricated with saliva, and formed into a cohesive mass known as the food bolus. Upon …

Current trends in pharmaceutical wet granulation have been shifted from traditional
approach to systematic and modern approaches, enabling the production of highly …

Assessment of the disintegration, dissolution and drug release profiles of oral drug
formulations are routinely performed by subjecting them to standard pharmacopeial test …

The objective of this study was to assess the contributions of surfactant-mediated solubility
and micellar diffusivity on the ability of surfactant to enhance drug dissolution. The following …

Since its inception, the dissolution test has come under increasing levels of scrutiny
regarding its relevance, especially to the correlation of results to levels of drug in blood. The …

ABSTRACT The USP Apparatus II is the device commonly used to conduct dissolution
testing in the pharmaceutical industry. Despite its widespread use, dissolution testing …

Dissolution is a crucial process for the oral delivery of drug products. Before being absorbed
through epithelial cell membranes to reach the systemic circulation, drugs must first dissolve …

Background Pharmaceutical salts of poorly soluble drugs typically dissolve faster than their
corresponding free acid or base, resulting in supersaturation under some circumstances …