Despite extensive research over many decades, human breast cancer remains a major
worldwide health concern. Advances in pre-clinical and clinical research has led to …

Simple Summary The high rate of cancers in both humans and in animals along with their
poor overall survival pose a major challenge in medicine. Therefore, a large amount of …

We present a new de novo transcriptome assembler, Bridger, which takes advantage of
techniques employed in Cufflinks to overcome limitations of the existing de novo …

Genomic and precision medicine research has afforded notable advances in human cancer
treatment, yet applicability to other species remains uncertain. Through whole-exome and …

Purpose Dogs have been proposed as spontaneous animal models of human breast
cancer, based on clinicopathologic similarities between canine and human mammary …

Spontaneous canine cancers are valuable but relatively understudied and underutilized
models. To enhance their usage, we reanalyze whole exome and genome sequencing data …

Spontaneous tumors in canines share significant genetic and histological similarities with
human tumors, positioning them as valuable models to guide drug development. However …

Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …

Canine malignant melanoma, a significant cause of mortality in domestic dogs, is a powerful
comparative model for human melanoma, but little is known about its genetic etiology. We …

Since the annotation of its genome a decade ago, the dog has proven to be an excellent
model for the study of inherited diseases. A large variety of spontaneous simple and …