Targeting IL-6 trans-signalling: past, present and future prospects

S Rose-John, BJ Jenkins, C Garbers, JM Moll… - Nature Reviews …, 2023 - nature.com
Abstract Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the
pathogenesis of diverse diseases, including autoimmune diseases, chronic inflammatory …

KRAS mutation: from undruggable to druggable in cancer

L Huang, Z Guo, F Wang, L Fu - Signal transduction and targeted …, 2021 - nature.com
Cancer is the leading cause of death worldwide, and its treatment and outcomes have been
dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene …

IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality

H Zhang, P Neuhöfer, L Song, B Rabe… - The Journal of …, 2013 - Am Soc Clin Investig
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although
typically seen in individuals with sepsis, ALI is also a major complication in severe acute …

Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment

LD Wood, MI Canto, EM Jaffee, DM Simeone - Gastroenterology, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is a clinically challenging cancer, due to both its
late stage at diagnosis and its resistance to chemotherapy. However, recent advances in our …

IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

Cell death in pancreatic cancer: from pathogenesis to therapy

X Chen, HJ Zeh, R Kang, G Kroemer… - Nature reviews …, 2021 - nature.com
Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer

KM McAndrews, Y Chen, JK Darpolor, X Zheng… - Cancer discovery, 2022 - AACR
The tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) involves a
significant accumulation of fibroblasts as part of the host response to cancer. Using single …

The tumour microenvironment in pancreatic cancer—clinical challenges and opportunities

WJ Ho, EM Jaffee, L Zheng - Nature reviews Clinical oncology, 2020 - nature.com
Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumours
despite the use of multi-agent conventional chemotherapy regimens. Such poor outcomes …

Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer

L Buscail, B Bournet, P Cordelier - Nature reviews Gastroenterology & …, 2020 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is predicted to be the second most common
cause of death within the next 10 years. The prognosis for this disease is poor despite …

Epithelial memory of inflammation limits tissue damage while promoting pancreatic tumorigenesis

E Del Poggetto, IL Ho, C Balestrieri, EY Yen, S Zhang… - Science, 2021 - science.org
INTRODUCTION The association between tumors and inflammation is a long-established
clinical observation. Although many studies have demonstrated that the inflammatory …