Multiple lines of evidence have implicated brain-derived neurotrophic factor (BDNF) in
treatment-resistant depression (TRD). The aim of this synthesis was to determine the impact …

Serotonin modulates several physiological and cognitive pathways throughout the human
body that affect emotions, memory, sleep, and thermal regulation. The complex nature of the …

Ethnopharmacological relevance Saffron, the dried stigma of Crocus sativus L., has a long
history of use in the treatment of depression in traditional Chinese medicine and Islamic …

The neuroimmune mechanism underlying neuropathic pain has been extensively studied.
Tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine that drives cytokine …

As a widely-known neuropsychiatric disorder, the exact pathogenesis of depression remains
elusive. MiRNA-206 (miR-206) is conventionally known as one of the myomiRs and has two …

Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

Chrysin (5, 7-dihydroxyflavone) is a flavonoid isolated from plants, such as Passiflora
coerulea, Passiflora incarnata, and Matricaria chamomilla. This natural molecule exerts …

Background Diosgenin is a well-known steroid saponin possessing neuroprotective
activities. However, it is unknown whether diosgenin could alleviate depression-like …

Background Depression is a severe mental illness that endangers human health.
Depressed individuals are prone to sleep less and to the loss of appetite for food; their …

Sarcopenia has an insidious start that can induce physical malfunction, raise the risk of falls,
disability, and mortality in the old, severely impair the aged persons' quality of life and …