Biosynthesis of milk fat, protein, and lactose: roles of transcriptional and posttranscriptional regulation

JS Osorio, J Lohakare, M Bionaz - Physiological genomics, 2016 - journals.physiology.org
The demand for high-quality milk is increasing worldwide. The efficiency of milk synthesis
can be improved by taking advantage of the accumulated knowledge of the transcriptional …

Primate milk: proximate mechanisms and ultimate perspectives

K Hinde, LA Milligan - Evolutionary Anthropology: Issues, News …, 2011 - Wiley Online Library
To understand the evolutionary forces that have shaped primate lactation strategies, it is
important to understand the proximate mechanisms of milk synthesis and their ecological …

Gene networks driving bovine milk fat synthesis during the lactation cycle

M Bionaz, JJ Loor - BMC genomics, 2008 - Springer
Background The molecular events associated with regulation of milk fat synthesis in the
bovine mammary gland remain largely unknown. Our objective was to study mammary …

Gene networks driving bovine mammary protein synthesis during the lactation cycle

M Bionaz, JJ Loor - Bioinformatics and biology insights, 2011 - journals.sagepub.com
A crucial role for both insulin and mTOR in the regulation of milk protein synthesis is
emerging. Bovine mammary biopsies harvested during late-pregnancy through end of …

Transcriptional profiling of bovine milk using RNA sequencing

S Wickramasinghe, G Rincon, A Islas-Trejo… - BMC genomics, 2012 - Springer
Background Cow milk is a complex bioactive fluid consumed by humans beyond infancy.
Even though the chemical and physical properties of cow milk are well characterized, very …

RNA sequencing of the human milk fat layer transcriptome reveals distinct gene expression profiles at three stages of lactation

DG Lemay, OA Ballard, MA Hughes, AL Morrow… - PloS one, 2013 - journals.plos.org
Aware of the important benefits of human milk, most US women initiate breastfeeding but
difficulties with milk supply lead some to quit earlier than intended. Yet, the contribution of …

Loss of epigenetic regulation disrupts lineage integrity, induces aberrant alveogenesis, and promotes breast cancer

E Langille, KN Al-Zahrani, Z Ma, M Liang… - Cancer …, 2022 - aacrjournals.org
Systematically investigating the scores of genes mutated in cancer and discerning disease
drivers from inconsequential bystanders is a prerequisite for precision medicine but remains …

The bovine lactation genome: insights into the evolution of mammalian milk

DG Lemay, DJ Lynn, WF Martin, MC Neville, TM Casey… - Genome biology, 2009 - Springer
Abstract Background The newly assembled Bos taurus genome sequence enables the
linkage of bovine milk and lactation data with other mammalian genomes. Results Using …

[HTML][HTML] Invited review: Current representation and future trends of predicting amino acid utilization in the lactating dairy cow

SIA Apelo, JR Knapp, MD Hanigan - Journal of Dairy Science, 2014 - Elsevier
In current dairy production systems, an average of 25% of dietary N is captured in milk, with
the remainder being excreted in urine and feces. About 60% of total N losses occur …

Evolution of lactation: ancient origin and extreme adaptations of the lactation system

CM Lefèvre, JA Sharp… - Annual review of genomics …, 2010 - annualreviews.org
Lactation, an important characteristic of mammalian reproduction, has evolved by exploiting
a diversity of strategies across mammals. Comparative genomics and transcriptomics …