Genetic Testing in Acute and Chronic Pancreatitis
I Piseddu, J Vielhauer, J Mayerle - Current Treatment Options in …, 2022 - Springer
Purpose of review Premature intracellular activation of pancreatic zymogens leads to the
initiation of pancreatitis, which in up to 25% leads to chronic tissue destruction, exocrine and …
initiation of pancreatitis, which in up to 25% leads to chronic tissue destruction, exocrine and …
Structural and biophysical insights into SPINK1 bound to human cationic trypsin
(1) The serine protease inhibitor Kazal type 1 (SPINK1) inhibits trypsin activity in zymogen
granules of pancreatic acinar cells. Several mutations in the SPINK1 gene are associated …
granules of pancreatic acinar cells. Several mutations in the SPINK1 gene are associated …
Chronic Pancreatitis: The True Pathogenic Culprit within the SPINK1 N34S-Containing Haplotype Is No Longer at Large
A diverse range of loss-of-function variants in the SPINK1 gene (encoding pancreatic
secretory trypsin inhibitor) has been identified in patients with chronic pancreatitis (CP). The …
secretory trypsin inhibitor) has been identified in patients with chronic pancreatitis (CP). The …
Fundamental redesign of the tiger2hs kernel to address severe parameter sensitivity
Replica exchange molecular dynamics simulations are one of the most popular approaches
to enhance conformational sampling of molecular systems. Applications range from protein …
to enhance conformational sampling of molecular systems. Applications range from protein …
Mechanisms in Systemic Inflammation
Acute pancreatitis is the consequence of proteolytically induced cell death of acinar cells.
The resulting damage triggers an immune response, which ultimately spreads and induces …
The resulting damage triggers an immune response, which ultimately spreads and induces …
Structural and Biophysical Insights into Autoproteolytic and Inhibitory Mechanisms Regulating Tryptic Activity in Pancreatitis
F Nagel - 2022 - epub.ub.uni-greifswald.de
Pancreatitis is an inflammatory disorder of the pancreas with a mortality rate of 5% and
severe negative effects on the quality of life. Of all non-malignant gastrointestinal diseases, it …
severe negative effects on the quality of life. Of all non-malignant gastrointestinal diseases, it …
[PDF][PDF] Genetic Testing in Acute and Chronic Pancreatitis
MD Ignazio Piseddu - 2022 - d-nb.info
Purpose of review Premature intracellular activation of pancreatic zymogens leads to the
initiation of pancreatitis, which in up to 25% leads to chronic tissue destruction, exocrine and …
initiation of pancreatitis, which in up to 25% leads to chronic tissue destruction, exocrine and …