[HTML][HTML] The role of focal therapy in the management of localised prostate cancer: a systematic review

M Valerio, HU Ahmed, M Emberton, N Lawrentschuk… - European urology, 2014 - Elsevier
Context The incidence of localised prostate cancer is increasing worldwide. In light of recent
evidence, current, radical, whole-gland treatments for organ-confined disease have being …

Oncological results and cancer control definition in focal therapy for prostate cancer: a systematic review

R Nicoletti, A Alberti, D Castellani, CH Yee… - Prostate Cancer and …, 2024 - nature.com
Introduction Focal therapy (FT) is a promising alternative to whole-gland treatments for
Localized Prostate Cancer. Ten different FT modalities have been described in literature …

[HTML][HTML] A multicentre study of 5-year outcomes following focal therapy in treating clinically significant nonmetastatic prostate cancer

S Guillaumier, M Peters, M Arya, N Afzal, S Charman… - European urology, 2018 - Elsevier
Background Clinically significant nonmetastatic prostate cancer (PCa) is currently treated
using whole-gland therapy. This approach is effective but can have urinary, sexual, and …

Cancer control outcomes following focal therapy using high-intensity focused ultrasound in 1379 men with nonmetastatic prostate cancer: a multi-institute 15-year …

D Reddy, M Peters, TT Shah, M van Son, MB Tanaka… - European Urology, 2022 - Elsevier
Background Focal therapy aims to treat areas of cancer to confer oncological control whilst
reducing treatment-related functional detriment. Objective To report oncological outcomes …

Focal therapy for localised unifocal and multifocal prostate cancer: a prospective development study

HU Ahmed, RG Hindley, L Dickinson… - The lancet …, 2012 - thelancet.com
Background Radical whole-gland therapy can lead to significant genitourinary and rectal
side-effects for men with localised prostate cancer. We report on whether selective focal …

The index lesion and the origin of prostate cancer

HU Ahmed - New England Journal of Medicine, 2009 - Mass Medical Soc
The Index Lesion and the Origin of Prostate Cancer | New England Journal of Medicine Skip to
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Prospective assessment of prostate cancer aggressiveness using 3-T diffusion-weighted magnetic resonance imaging–guided biopsies versus a systematic 10-core …

T Hambrock, C Hoeks, C Hulsbergen-Van De Kaa… - European urology, 2012 - Elsevier
BACKGROUND: Accurate pretreatment assessment of prostate cancer (PCa)
aggressiveness is important in decision making. Gleason grade is a critical predictor of the …

Early-medium-term outcomes of primary focal cryotherapy to treat nonmetastatic clinically significant prostate cancer from a prospective multicentre registry

TT Shah, M Peters, D Eldred-Evans, S Miah, T Yap… - European urology, 2019 - Elsevier
Background Focal cryotherapy can be used to treat patients with clinically significant
nonmetastatic prostate cancer to reduce side effects. Objective Early-medium-term cancer …

Focal ablation targeted to the index lesion in multifocal localised prostate cancer: a prospective development study

HU Ahmed, L Dickinson, S Charman, S Weir… - European urology, 2015 - Elsevier
Background Although localised prostate cancer is multifocal in most instances, the index
lesion might be responsible for disease progression. Objective To determine the early …

Is it time to consider a role for MRI before prostate biopsy?

HU Ahmed, A Kirkham, M Arya, R Illing… - Nature reviews Clinical …, 2009 - nature.com
The use of MRI in prostate cancer management is controversial and current guidelines
underplay its role. Technological advances over the past 5 years, however, demand a re …