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Cap** protein regulators fine-tune actin assembly dynamics
Cap** protein (CP) binds the fast growing barbed end of the actin filament and regulates
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …
actin assembly by blocking the addition and loss of actin subunits. Recent studies provide …
The small G proteins of the Arf family and their regulators
Small G proteins play a central role in the organization of the secretory and endocytic
pathways. The majority of such small G proteins are members of the Rab family, which are …
pathways. The majority of such small G proteins are members of the Rab family, which are …
Convergence of genes and cellular pathways dysregulated in autism spectrum disorders
Rare copy-number variation (CNV) is an important source of risk for autism spectrum
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of …
disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of …
The Cbl interactome and its functions
Cbl proteins are ubiquitin ligases and multifunctional adaptor proteins that are implicated in
the regulation of signal transduction in various cell types and in response to different stimuli …
the regulation of signal transduction in various cell types and in response to different stimuli …
Actin regulation in endocytosis
Increasing evidence from a variety of cell types has highlighted the importance of the actin
cytoskeleton during endocytosis. No longer is actin viewed as a passive barrier that must be …
cytoskeleton during endocytosis. No longer is actin viewed as a passive barrier that must be …
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes
Podocytes are specialized cells that play an integral role in the renal glomerular filtration
barrier via their foot processes. The foot processes form a highly organized structure, the …
barrier via their foot processes. The foot processes form a highly organized structure, the …
[PDF][PDF] The SH3 domain--a family of versatile peptide-and protein-recognition module
Introduction 3. Conventional and atypical sequence motifs 3.1. Canonical peptide motifs
recognized by the SH3 domains 3.2. Atypical SH3-binding motifs 3.3. The RxxK motif 4 …
recognized by the SH3 domains 3.2. Atypical SH3-binding motifs 3.3. The RxxK motif 4 …
Role of ubiquitylation in cellular membrane transport
Ubiquitylation of membrane proteins has gained considerable interest in recent years. It has
been recognized as a signal that negatively regulates the cell surface expression of many …
been recognized as a signal that negatively regulates the cell surface expression of many …
Regulation of actin cytoskeleton dynamics by Arf-family GTPases
Small GTPases of the Arf family are best known for their role in vesicular transport, wherein
they nucleate the assembly of coat proteins at sites of carrier vesicle formation. However …
they nucleate the assembly of coat proteins at sites of carrier vesicle formation. However …
Arf GAPs and their interacting proteins
Membrane trafficking and remodeling of the actin cytoskeleton are critical activities
contributing to cellular events that include cell growth, migration and tumor invasion. ADP …
contributing to cellular events that include cell growth, migration and tumor invasion. ADP …