BACKGROUND: Intervertebral disc (IVD) degeneration remains a clinically important
condition for which treatment is costly and relatively ineffective. The molecular basis of …

The prevalence of “vertebral endplate signal changes”(VESC) and its association with low
back pain (LBP) varies greatly between studies. This wide range in reported prevalence …

Abstract Background Context Modic changes (MC) are bone marrow lesions on magnetic
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …

Study Design. A cross-sectional population study of magnetic resonance imaging (MRI)
changes. Objective. To examine the pattern and prevalence of lumbar spine MRI changes …

BACKGROUND CONTEXT: Disc degeneration was commonly viewed over much of the last
century as a result of aging and “wear and tear” from mechanical insults and injuries. Thus …

The pathophysiology of intervertebral disc degeneration has been extensively studied.
Various factors have been suggested as influencing its aetiology, including mechanical …

Objective To investigate the association of being overweight or obese with the presence,
extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in …

Background: Little is known regarding juvenile disc degeneration in individuals with normal
spinal alignment. Consequently, the purpose of this study was to assess the prevalence …

Low back pain (LBP) is a major cause of disability and imposes huge economic burdens on
human society worldwide. Among many factors responsible for LBP, intervertebral disc …

BACKGROUND CONTEXT: Disc degeneration (DD) is a multifaceted chronic process that
alters the structure and function of the intervertebral discs and can lead to painful conditions …