Regulation and roles of bicarbonate transporters in cancer

A Gorbatenko, CW Olesen, E Boedtkjer… - Frontiers in …, 2014 - frontiersin.org
A unifying feature of solid tumors is a markedly altered pH profile compared to normal
tissues. This reflects that solid tumors, despite completely different origins, often share …

Mucin 13: structure, function, and potential roles in cancer pathogenesis

DM Maher, BK Gupta, S Nagata, M Jaggi… - Molecular Cancer …, 2011 - aacrjournals.org
Abstract Mucin 13 (MUC13) is a high-molecular-weight transmembrane glycoprotein that is
frequently and aberrantly expressed in a variety of epithelial carcinomas, including gastric …

Identification of hub genes related to carcinogenesis and prognosis in colorectal cancer based on integrated bioinformatics

B Gong, Y Kao, C Zhang, F Sun… - Mediators of …, 2020 - Wiley Online Library
The high mortality of colorectal cancer (CRC) patients and the limitations of conventional
tumor‐node‐metastasis (TNM) stage emphasized the necessity of exploring hub genes …

Solute carrier transporters: potential targets for digestive system neoplasms

J **e, XY Zhu, LM Liu, ZQ Meng - Cancer Management and …, 2018 - Taylor & Francis
Digestive system neoplasms are the leading causes of cancer-related death all over the
world. Solute carrier (SLC) superfamily is composed of a series of transporters that are …

The effect of genetic variants of SLC22A18 on proliferation, migration, and invasion of colon cancer cells

HS Song, SY Ha, JY Kim, M Kim, JH Choi - Scientific reports, 2024 - nature.com
Solute carrier family (SLC) transporters are expressed in the digestive system and play
important roles in maintaining physiological functions in the body. In addition, SLC …

Systematic large-scale meta-analysis identifies a panel of two mRNAs as blood biomarkers for colorectal cancer detection

MT Rodia, G Ugolini, G Mattei, I Montroni… - …, 2016 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) is the third most common cancer in the world. A significant survival
rate is achieved if it is detected at an early stage. A whole blood screening test, without any …

Common molecular markers between circulating tumor cells and blood exosomes in colorectal cancer: a systematic and analytical review

S Vafaei, F Fattahi, M Ebrahimi, L Janani… - Cancer management …, 2019 - Taylor & Francis
Nearly half of patients with colorectal cancer (CRC), the third leading cause of cancer deaths
worldwide, are diagnosed in the late stages of the disease. Appropriate treatment is not …

SLC26A3/NHERF2-IκB/NFκB/p65 feedback loop suppresses tumorigenesis and metastasis in colorectal cancer

C Lin, P Lin, H Lin, H Yao, S Liu, R He, H Chen, Z Teng… - Oncogenesis, 2023 - nature.com
Colorectal cancer (CRC) is a formidable disease due to the intricate mechanisms that drive
its proliferation and metastasis. Despite significant progress in cancer research, the …

LGALS4, CEACAM6, TSPAN8, and COL1A2: Blood markers for colorectal cancer—validation in a cohort of subjects with positive fecal immunochemical test result

MT Rodia, R Solmi, F Pasini, E Nardi, G Mattei… - Clinical colorectal …, 2018 - Elsevier
Background A noninvasive blood test for the early detection of colorectal cancer (CRC) is
highly required. We evaluated a panel of 4 mRNAs as putative markers of CRC. Materials …

Mining the dark matter of the cancer proteome for novel biomarkers

A Paula Delgado, P Brandao, S Hamid… - Current Cancer …, 2013 - benthamdirect.com
The post genome era has ushered us into therapeutic target discovery empowering us to
mine the genome using rational approaches. Numerous cancer targets have emerged from …