[PDF][PDF] Mouth breathing: adverse effects on facial growth, health, academics, and behavior

Y Jefferson - Gen Dent, 2010‏ - thehealthlodge.com.au
The importance of facial appear-ances in contemporary society is undeniable. Many studies
have shown that individuals with attractive facial features are more readily accepted than …

Clinical update on the use of biomarkers of airway inflammation in the management of asthma

SJ Wadsworth, DD Sin… - Journal of asthma and …, 2011‏ - Taylor & Francis
Biological markers are already used in the diagnosis and treatment of cardiovascular
disease and cancer. Biomarkers have great potential use in the clinic as a noninvasive …

Exhaled nitric oxide: a biomarker integrating both lung function and airway inflammation changes

A Haccuria, A Michils, S Michiels… - Journal of allergy and …, 2014‏ - Elsevier
Background The increased fraction of exhaled nitric oxide (F eno) values observed in
asthmatic patients are thought to reflect increased airway inflammation. However, F eno …

Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma

JR Arron, DF Choy, H Scheerens… - Annals of the American …, 2013‏ - atsjournals.org
Although human asthma is commonly regarded as an allergic disorder characterized by type
2 cytokine expression and eosinophilic inflammation in the airways, it is clearly …

HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages

RM Carey, BM Hariri, ND Adappa, JN Palmer, RJ Lee - Cells, 2022‏ - mdpi.com
Bitter taste receptors (T2Rs) are G protein-coupled receptors (GPCRs) expressed in various
cell types including ciliated airway epithelial cells and macrophages. T2Rs in these two …

Organs-on-a-chip: A new paradigm for toxicological assessment and preclinical drug development

D Bovard, A Iskandar, K Luettich… - Toxicology …, 2017‏ - journals.sagepub.com
In the last few years, considerable attention has been given to in vitro models in an attempt
to reduce the use of animals and to decrease the rate of preclinical failure associated with …

Do small airway abnormalities characterize asthma phenotypes? In search of proof

M Contoli, M Kraft, Q Hamid, J Bousquet… - Clinical & …, 2012‏ - Wiley Online Library
The role of small airway abnormalities in asthma pathogenesis has been extensively studied
and debated for several decades. However, whether or not small airway abnormalities play …

The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1?

N Scichilone, S Battaglia, D Olivieri, V Bellia - Allergy, 2009‏ - Wiley Online Library
The definition of asthma has evolved from that of an episodic disease characterized by
reversible airways constriction to a chronic inflammatory disease of the airways, with at least …

Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics

J Stefanska, A Sarniak, A Wlodarczyk… - Experimental lung …, 2012‏ - Taylor & Francis
Asthma is an inflammatory airway disease, and oxidative stress was proven to be involved in
its pathogenesis. Apocynin effectively inhibits the main source of reactive oxygen species …

Role of periostin, FENO, IL-13, lebrikzumab, other IL-13 antagonist and dual IL-4/IL-13 antagonist in asthma

S Agrawal, RG Townley - Expert Opinion on Biological Therapy, 2014‏ - Taylor & Francis
Introduction: Asthma markedly diminishes quality of life due to limited activity, absences from
work or school and hospitalizations. Patients with severe asthma which are not controlled …