Intensive selection pressure constrains the evolutionary trajectory of SARS-CoV-2 genomes
and results in various novel variants with distinct mutation profiles. Point mutations …

Over the last three years, the pandemic of COVID-19 has had a significant impact on
people's lives and the global economy. The incessant emergence of variant strains has …

The unceasing circulation of SARS-CoV-2 leads to the continuous emergence of novel viral
sublineages. Here, we isolate and characterize XBB. 1, XBB. 1.5, XBB. 1.9. 1, XBB. 1.16. 1 …

A severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant, BA.
2.86, has emerged and spread to numerous countries worldwide, raising alarm because its …

COVID-19 vaccines have recently been updated to specifically encode or contain the spike
protein of the SARS-CoV-2 XBB. 1.5 subvariant, but their immunogenicity in humans has yet …

Evolution of SARS-CoV-2 requires the reassessment of current vaccine measures. Here, we
characterized BA. 2.86 and XBB-derived variant FLip by investigating their neutralization …

Immune evasion by SARS-CoV-2 paired with immune imprinting from monovalent mRNA
vaccines has resulted in attenuated neutralizing antibody responses against Omicron …

ABSTRACT The highly mutated BA. 2.86, with over 30 spike protein mutations in
comparison to Omicron BA. 2 and XBB. 1.5 variants, has raised concerns about its potential …

The recently dominant SARS-CoV-2 Omicron JN. 1 has evolved into multiple sublineages,
with recurrent spike mutations R346T, F456L, and T572I, some of which exhibit growth …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolution has resulted in
viral escape from clinically authorized monoclonal antibodies (mAbs), creating a need for …