Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Being opportunistic intracellular pathogens, viruses are dependent on the host for their
replication. They hijack host cellular machinery for their replication and survival by targeting …

ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers
of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-related
CoVs encode 3 tandem macrodomains within nonstructural protein 3 (nsp3). The first …

Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several
families of RNA viruses and have recently been shown to counter innate immune responses …

Hepatitis E virus (HEV) possesses many of the features of other positive-stranded RNA
viruses but also adds HEV-specific nuances, making its virus–host interactions unique. Slow …

Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains
limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP …

Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families​ all contain genes
that encode a conserved protein domain, called a macrodomain; however, the role of this …

Hepatitis E virus (HEV) is one of the most common causes of acute viral hepatitis, mainly
transmitted by fecal-oral route but has also been linked to fulminant hepatic failure, chronic …

Hepatitis E virus (HEV) is a viral pathogen transmitted primarily via fecal-oral route. In
humans, HEV mainly causes acute hepatitis and is responsible for large outbreaks of …