The uptake of macromolecules and larger energy-rich particles into the cell is known as
phagocytosis. Phagocytosed material is enzymatically degraded in membrane-bound …

In recent years, the mathematical and computational sciences have developed novel
methodologies and insights that can aid in designing advanced bioreactors, microfluidic …

Predicting biological systems' behaviors requires taking into account many molecular and
genetic elements for which limited information is available past a global knowledge of their …

Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of
recognizing tumor-associated antigens (TAA) and eradicating malignant cells. Here, we …

Analysing models of biological networks typically relies on workflows in which different
software tools with sensitive parameters are chained together, many times with additional …

Complex living systems are thought to exist at the “edge of chaos” separating the ordered
dynamics of robust function from the disordered dynamics of rapid environmental …

The logical formalism is well adapted to model large cellular networks, in particular when
detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative …

Recently, we described B-cell precursor acute lymphoblastic leukemia (BCP-ALL) subtype
with an early switch to the monocytic lineage and the loss of the B-cell immunophenotype …

Organisms utilize gene regulatory networks (GRN) to make fate decisions, but the regulatory
mechanisms of transcription factors (TF) in GRNs are exceedingly intricate. A longstanding …

Hematopoietic stem cell (HSC) aging is a multifactorial event leading to changes in HSC
properties and functions, which are intrinsically coordinated and affect the early …