Background Polyneuropathies (peripheral neuropathies) are the most common type of
disorder of the peripheral nervous system in adults, and specifically in the elderly, with an …

Introduction Levodopa/carbidopa intestinal gel (LCIG; carbidopa/levodopa enteral
suspension) has been widely used and studied for the treatment of motor fluctuations in …

Subcutaneous apomorphine infusion (Apo) and intrajejunal levodopa infusion (IJLI) are two
treatment options for patients with advanced Parkinson's disease (PD) and refractory motor …

The deposition of alpha-synuclein in the brain, the neuropathological hallmark of
Parkinson's disease (PD), follows a distinct anatomical and temporal sequence. This study …

Although levodopa remains the most effective drug for symptomatic management of
Parkinson's Disease (PD), treatment during advanced disease stages may raise …

Background Clinical, neurophysiological, and pathological evidence suggest an association
between Parkinson's disease (PD) and peripheral neuropathy (PNP), with a possible …

Background Parkinson's disease (PD) has been associated with peripheral neuropathy
(PN). PN has been demonstrated in some rare genetic forms of PD (eg PARK2 mutations) …

Enterally administered levodopa/carbidopa gel (Duodopa®) is used for the treatment of
advanced Parkinson's disease (PD) in patients with motor fluctuations and dyskinesias. This …

In advanced Parkinson's disease (PD) patients, continuous intra-duodenal infusion of
levodopa/carbidopa intestinal gel (LCIG) is an established approach in the management of …

Background Recent reports suggest increased frequency of peripheral neuropathy (PN) in
Parkinson's disease (PD) patients on levodopa compared with age-matched controls …