Early adolescent substance use dramatically increases the risk of lifelong substance use
disorder (SUD). An adolescent sensitive period evolved to allow the development of risk …

There are over twenty rodent models of Attention-Deficit Hyperactivity Disorder (ADHD), with
most reflecting a recognized ADHD subtype. Of these, only five rat models (Neonatal 6 …

Attention‐deficit hyperactivity disorder (ADHD) is a heterogeneous neuropsychiatric disorder
characterized by three primary symptoms hyperactivity, attention deficit, and impulsiveness …

Dopamine (DA) signaling is critical to the modulation of multiple brain functions including
locomotion, reinforcement, attention and cognition. The literature provides strong evidence …

Impulsivity and hyperactivity are two facets of attention deficit/hyperactivity disorder (ADHD).
Impulsivity is expressed as reduced response inhibition capacity, an executive control …

Corticostriatal circuitry supports flexible reward learning and emotional behavior from the
critical neurodevelopmental stage of adolescence through adulthood. It is still poorly …

Attention-deficit/hyperactivity disorder (ADHD) is comorbid with cocaine abuse. Whereas
initiating ADHD medication in childhood does not alter later cocaine abuse risk, initiating …

Rationale Both methylphenidate (MPH), a catecholamine reuptake blocker, and guanfacine,
an alpha2A agonist, are used to treat attention-deficit hyperactivity disorder (ADHD) …

Rationale Stimulant medications for attention-deficit/hyperactivity disorder (ADHD) in
adolescents remain controversial with respect to later development of cocaine abuse. Past …

About 20% of individuals with attention deficit hyperactivity disorder are first diagnosed
during adolescence. While preclinical experiments suggest that adolescent-onset exposure …