Important flavonoids and their role as a therapeutic agent

A Ullah, S Munir, SL Badshah, N Khan, L Ghani… - Molecules, 2020 - mdpi.com
Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and
leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of …

Molecular mechanisms of neurodegeneration in Alzheimer's disease

L Crews, E Masliah - Human molecular genetics, 2010 - academic.oup.com
Alzheimer's disease (AD) is characterized by cognitive impairment, progressive
neurodegeneration and formation of amyloid-β (Aβ)-containing plaques and neurofibrillary …

Neurodegenerative disease and adult neurogenesis

B Winner, Z Kohl, FH Gage - European Journal of Neuroscience, 2011 - Wiley Online Library
The generation and cell death of newly generated cells have critical roles in brain
development and maintenance in the embryonic and adult brain. Alterations in these …

Resveratrol: a focus on several neurodegenerative diseases

E Tellone, A Galtieri, A Russo… - … medicine and cellular …, 2015 - Wiley Online Library
Molecules of the plant world are proving their effectiveness in countering, slowing down, and
regressing many diseases. The resveratrol for its intrinsic properties related to its stilbene …

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model

L Hoeijmakers, SR Ruigrok, A Amelianchik… - Brain, behavior, and …, 2017 - Elsevier
Exposure to stress during the sensitive period of early-life increases the risk to develop
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …

The Toxicity of Amyloid β Oligomers

LN Zhao, HW Long, Y Mu, LY Chew - International journal of molecular …, 2012 - mdpi.com
In this review, we elucidate the mechanisms of A β oligomer toxicity which may contribute to
Alzheimer's disease (AD). In particular, we discuss on the interaction of A β oligomers with …

B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE …

A Fuso, V Nicolia, RA Cavallaro, L Ricceri… - Molecular and cellular …, 2008 - Elsevier
Etiological and molecular studies on the sporadic form of Alzheimer's disease have yet to
determine the underlying mechanisms of neurodegeneration. Hyperhomocysteinemia is …

Increased accumulation of intraneuronal amyloid β in HIV-infected patients

CL Achim, A Adame, W Dumaop, IP Everall… - Journal of Neuroimmune …, 2009 - Springer
In recent years, human immunodeficiency virus (HIV)-infected patients under highly active
anti-retroviral therapy (HAART) regimens have shown a markedly improved general clinical …

Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection

M Pallàs, G Casadesús, MA Smith… - Current …, 2009 - ingentaconnect.com
One of the current problems in medicine research is the development of safe drugs for the
treatment of neurological disorders. Furthermore, there is a close relationship between the …

Protective effects of flavonoids against Alzheimer's disease-related neural dysfunctions

M Bakhtiari, Y Panahi, J Ameli, B Darvishi - Biomedicine & …, 2017 - Elsevier
Senile ages of human life is mostly associated with developmental of several neurological
complicated conditions including decreased cognition and reasoning, increased memory …