[HTML][HTML] Host immune response against leishmaniasis and parasite persistence strategies: A review and assessment of recent research

EK Elmahallawy, AAM Alkhaldi, AA Saleh - Biomedicine & …, 2021 - Elsevier
Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

Role of chemokines in regulation of immunity against leishmaniasis

S Oghumu, CM Lezama-Dávila… - Experimental …, 2010 - Elsevier
Successful immunity to Leishmania depends on recruitment of appropriate immune effector
cells to the site of infection and chemokines play a crucial role in the process. At the same …

Immune responses during cutaneous and visceral leishmaniasis

L Kedzierski, KJ Evans - Parasitology, 2014 - cambridge.org
Leishmania are protozoan parasites spread by a sandfly insect vector and causing a
spectrum of diseases collectively known as leishmaniasis. The disease is a significant …

Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis

A Saha, A Biswas, S Srivastav… - The Journal of …, 2014 - journals.aai.org
Persistence of intracellular infection depends on the exploitation of factors that negatively
regulate the host immune response. In this study, we elucidated the role of macrophage …

Comparative transcriptomic analysis of antimony resistant and susceptible Leishmania infantum lines

JM Andrade, LO Gonçalves, DB Liarte, DA Lima… - Parasites & …, 2020 - Springer
Background One of the major challenges to leishmaniasis treatment is the emergence of
parasites resistant to antimony. To study differentially expressed genes associated with drug …

Annonaceae: breaking the wall of inflammation

A Attiq, J Jalil, K Husain - Frontiers in pharmacology, 2017 - frontiersin.org
Inventories of tropical forests have listed Annonaceae as one of the most diverse plant
families. For centuries, it is employed in traditional medicines to cure various pathological …

[HTML][HTML] Immunotherapeutic Strategies as Potential Treatment Options for Cutaneous Leishmaniasis

A Lafleur, S Daffis, C Mowbray, B Arana - Vaccines, 2024 - mdpi.com
Cutaneous leishmaniasis (CL), caused by protozoan parasites of the Leishmania genus, is
prevalent in tropical and subtropical regions, with important morbidity, particularly in low-to …

Immunity to visceral leishmaniasis using genetically defined live‐attenuated parasites

A Selvapandiyan, R Dey, S Gannavaram… - Journal of tropical …, 2012 - Wiley Online Library
Leishmaniasis is a protozoan parasitic disease endemic to the tropical and subtropical
regions of the world, with three major clinical forms, self‐healing cutaneous leishmaniasis …

Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable …

JA Fiuza, R Dey, D Davenport… - PLoS neglected …, 2016 - journals.plos.org
Background Visceral leishmaniasis (VL) is a neglected tropical disease and is fatal if
untreated. There is no vaccine available against leishmaniasis. The majority of patients with …

G1-4A, a Polysaccharide from Tinospora cordifolia Inhibits the Survival of Mycobacterium tuberculosis by Modulating Host Immune Responses in TLR4 Dependent …

PK Gupta, P Chakraborty, S Kumar, PK Singh… - PloS one, 2016 - journals.plos.org
Rapid emergence of drug resistance in Mycobacterium tuberculosis (MTB) is a major health
concern and demands the development of novel adjunct immunotherapeutic agents capable …