Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Nitrosative stress results from an increase in reactive nitrogen species (RNS) within the cell.
Though the RNS–nitric oxide (· NO) and peroxynitrite (ONOO−)–play pivotal physiological …

Production of inorganic polyphosphate (polyP) by bacteria is triggered by a variety of
different stress conditions. polyP is required for stress survival and virulence in diverse …

RNA polymerase is the only known protein partner of the transcriptional regulator DksA.
Herein, we demonstrate that the chaperone DnaJ establishes direct, redox-based …

The adaptations that protect pathogenic microorganisms against the cytotoxicity of nitric
oxide (NO) engendered in the immune response are incompletely understood. We show …

Genetic and dietary forms of iron overload have distinctive clinical and pathophysiological
features. HFE-associated hereditary hemochromatosis is characterized by overwhelming …

Members of the Bacillus genus are industrial cell factories due to their capacity to secrete
significant quantities of biomolecules with industrial applications. The Bacillus …

DksA is a conserved RNA polymerase-binding protein known to play a key role in the
stringent response of proteobacteria species, including many gastrointestinal pathogens …

The bacterial stringent response is a response to nutrition deprivation and other stress
conditions. In Gram‐negative bacteria, this process is mediated by the small signal …

How anaerobic bacteria protect themselves against nitric oxide‐induced stress is
controversial, not least because far higher levels of stress were used in the experiments on …