Publisher Summary This chapter discusses the role of free radicals and catalytic metal ions
in human disease. The importance of transition metal ions in mediating oxidant damage …

Objectives In view of the critical role of intracellular Ca 2+-overload in the genesis of
myocyte dysfunction and the ability of reactive oxygen species (ROS) to induce the …

MATERIALS AND METHODS Surgical preparation. The experimental animals were handled
in compliance with the Guiding Principles in the Use and Care of Animals published by the …

The ability of zinc to retard oxidative processes has been recognized for many years. In
general, the mechanism of antioxidation can be divided into acute and chronic effects …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

This pocket-sized resource offers rapid, portable access to the most important facts and
concepts from Robbins and Cotran Pathologic Basis of Disease, 7th Edition. It is a superb …

Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

The past two decades have witnessed an explosive growth of knowledge regarding
postischemic myocardial dysfunction or myocardial “stunning.” The purpose of this review is …

After a brief discussion of lipid peroxidation mechanism and the action of antioxidants and
their potential to exhibit prooxidant effects, we give an overview on the clinical relevance of …

In experimental studies in the dog, total proximal coronary artery occlusions of up to 15
minutes result in reversible injury, meaning that the myocytes survive this insult. The 15 …