Activation and assembly of the NADPH oxidase: a structural perspective
Y Groem**, K Rittinger - Biochemical Journal, 2005 - portlandpress.com
The NADPH oxidase of professional phagocytes is a crucial component of the innate
immune response due to its fundamental role in the production of reactive oxygen species …
immune response due to its fundamental role in the production of reactive oxygen species …
Antimicrobial mechanisms of fish phagocytes and their role in host defense
Phagocytosis is a primitive defense mechanism in all multicellular animals. Phagocytes such
as macrophages and neutrophils play an important role in limiting the dissemination of …
as macrophages and neutrophils play an important role in limiting the dissemination of …
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2
UG Knaus, PG Heyworth, T Evans, JT Curnutte… - Science, 1991 - science.org
A major action of the microbicidal system of human neutrophils is the formation of
superoxide anion (O2-) by a multicomponent oxidase that transfers electrons from the …
superoxide anion (O2-) by a multicomponent oxidase that transfers electrons from the …
Enzymic mechanisms of superoxide production
AR Cross, OTG Jones - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1991 - Elsevier
The realization that superoxide, and other reactive oxygen species, is produced in
significant quantities in biological systems is a relatively recent one and the nature and …
significant quantities in biological systems is a relatively recent one and the nature and …
The superoxide‐generating oxidase of phagocytic cells: physiological, molecular and pathological aspects
F Morel, J Doussiere, PV Vignais - European Journal of …, 1991 - Wiley Online Library
Professional phagocytes (neutrophils, eosinophils, monocytes and macrophages) possess
an enzymatic complex, the NADPH oxidase, which is able to catalyze the one‐electron …
an enzymatic complex, the NADPH oxidase, which is able to catalyze the one‐electron …
Oxidative stress and living cells
G Gille, K Sigler - Folia Microbiologica, 1995 - Springer
The review deals with the effects of reactive oxygen species, both radical and nonradical (eg
hydrogen peroxide), on cells and organisms. The chemical and biochemical aspects include …
hydrogen peroxide), on cells and organisms. The chemical and biochemical aspects include …
NADPH oxidases in the vasculature: molecular features, roles in disease and pharmacological inhibition
Until the 1970s, reactive oxygen species (ROS) were considered merely harmful by-
products of aerobic respiration and the driving force behind the evolution of an array of …
products of aerobic respiration and the driving force behind the evolution of an array of …
Regulation of the neutrophil respiratory burst oxidase: identification of an activation domain in p67phox
CH Han, JLR Freeman, T Lee, SA Motalebi… - Journal of Biological …, 1998 - ASBMB
Superoxide generation by the neutrophil respiratory burst oxidase (NADPH oxidase) can be
reconstituted in a cell-free system using flavocytochrome b 558 and the cytosolic proteins …
reconstituted in a cell-free system using flavocytochrome b 558 and the cytosolic proteins …
Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task
E Pick - Small GTPases, 2014 - Taylor & Francis
The superoxide-generating NADPH oxidase of phagocytes consists of the membrane-
associated cytochrome b 558 (a heterodimer of Nox2 and p22 phox) and 4 cytosolic …
associated cytochrome b 558 (a heterodimer of Nox2 and p22 phox) and 4 cytosolic …
Chronic granulomatous disease
Several reports appeared in the paediatric literature between 1954 and 1960 which
described a clinical syndrome characterised by recurrent life threatening sepsis …
described a clinical syndrome characterised by recurrent life threatening sepsis …