Mechanical forces shape cells and tissues during development and adult homeostasis. In
addition, they also signal to cells via mechanotransduction pathways to control cell …

During division, eukaryotic cells undergo a dramatic, complex and coordinated remodelling
of their cytoskeleton and membranes. For cell division to occur, chromosomes must be …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Living tissues are active, multifunctional materials capable of generating, sensing,
withstanding and responding to mechanical stress. These capabilities enable tissues to …

While nanoscale modification of a biomaterial surface is known to influence various cell
behaviors, it is unclear whether there is an optimal nanospacing of a bioactive ligand with …

To enter mitosis, most adherent animal cells reduce adhesion, which is followed by cell
rounding. How mitotic cells regulate adhesion to neighboring cells and extracellular matrix …

In collective cell migration, the motion results from forces produced by each cell and
transmitted to the neighboring cells and to the substrate. Because inertia is negligible and …

Quantifying mechanical forces generated by cellular systems has led to key insights into a
broad range of biological phenomena from cell adhesion to immune cell activation. Traction …

Polyploidy is defined as a cell with three or more whole genome sets and enables cell
growth across the kingdoms of life. Studies in model organisms have revealed that polyploid …

The develo** heart is formed of two tissue layers separated by an extracellular matrix
(ECM) that provides chemical and physical signals to cardiac cells. While deposition of …