Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been
recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of …

The first total synthesis of icosalide A, an antibacterial depsipeptide that is unique in that it
contains two lipophilic beta-hydroxy acids, has been achieved by following Fmoc solid …

Innate defense regulators (IDRs) are synthetic host-defense peptides (HDPs) with broad-
spectrum anti-infective properties, including immunomodulatory, anti-biofilm and direct …

Short, cationic, amphipathic peptides are found as natural antimicrobial agents among all
life forms. These natural peptides and their synthetic analogs, collectively named host …

Nature presents a solution to drug resistant infections in the form of cationic host defense
peptides (CHDPs), such as LL-37, that exhibit wide-ranging antimicrobial, anti-biofilm, and …

Pseudomonas aeruginosa is an opportunistic pathogen that causes nosocomial and chronic
infections contributing to morbidity and mortality in skin wound and cystic fibrosis patients …