Aging in a dish: iPSC-derived and directly induced neurons for studying brain aging and age-related neurodegenerative diseases
Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …
research as we are still struggling to understand the interface between the aging process …
Mitochondrial aspects of synaptic dysfunction in Alzheimer's disease
Alzheimer's disease (AD) is characterized by brain deposition of amyloid plaques and tau
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …
neurofibrillary tangles along with steady cognitive decline. Synaptic damage, an early …
Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer's patients
Sporadic Alzheimer's disease (AD) exclusively affects elderly people. Using direct
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …
conversion of AD patient fibroblasts into induced neurons (iNs), we generated an age …
Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects
Aging is a major risk factor for many human diseases, and in vitro generation of human
neurons is an attractive approach for modeling aging-related brain disorders. However …
neurons is an attractive approach for modeling aging-related brain disorders. However …
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
C9orf72 mutations are the most common cause of amyotrophic lateral sclerosis (ALS) and
frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by …
frontotemporal dementia (FTD). Dipeptide repeat proteins (DPRs) produced by …
Developmental regulation of tau splicing is disrupted in stem cell-derived neurons from frontotemporal dementia patients with the 10+ 16 splice-site mutation in MAPT
The alternative splicing of the tau gene, MAPT, generates six protein isoforms in the adult
human central nervous system (CNS). Tau splicing is developmentally regulated and …
human central nervous system (CNS). Tau splicing is developmentally regulated and …
Tau isoforms imbalance impairs the axonal transport of the amyloid precursor protein in human neurons
V Lacovich, SL Espindola, M Alloatti… - Journal of …, 2017 - Soc Neuroscience
Tau, as a microtubule (MT)-associated protein, participates in key neuronal functions such
as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative …
as the regulation of MT dynamics, axonal transport, and neurite outgrowth. Alternative …
Tau physiology and pathomechanisms in frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) has been associated with toxic intracellular
aggregates of hyperphosphorylated tau (FTLD‐tau). Moreover, genetic studies identified …
aggregates of hyperphosphorylated tau (FTLD‐tau). Moreover, genetic studies identified …
Next‐generation disease modeling with direct conversion: a new path to old neurons
Within just over a decade, human reprogramming‐based disease modeling has developed
from a rather outlandish idea into an essential part of disease research. While iPSCs are a …
from a rather outlandish idea into an essential part of disease research. While iPSCs are a …
Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons
Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia
nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD …
nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD …