Towards organoid culture without Matrigel
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …
function in miniature—are of growing interest in developmental biology and medicine …
Advanced therapy to cure diabetes: mission impossible is now possible?
R Rohban, CP Martins, F Esni - Frontiers in Cell and Developmental …, 2024 - frontiersin.org
Cell and Gene therapy are referred to as advanced therapies that represent overlap**
fields of regenerative medicine. They have similar therapeutic goals such as to modify …
fields of regenerative medicine. They have similar therapeutic goals such as to modify …
A matrigel-free method for culture of pancreatic endocrine-like cells in defined protein-based hydrogels
The transplantation of pancreatic endocrine islet cells from cadaveric donors is a promising
treatment for type 1 diabetes (T1D), which is a chronic autoimmune disease that affects …
treatment for type 1 diabetes (T1D), which is a chronic autoimmune disease that affects …
β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells
Thorough research on the capacity of human islet transplantation to cure type 1 diabetes led
to the achievement of 3-to 5-year-long insulin independence in nearly half of transplanted …
to the achievement of 3-to 5-year-long insulin independence in nearly half of transplanted …
Postnatal pancreas of mice contains tripotent progenitors capable of giving rise to duct, acinar, and endocrine cells in vitro
Postnatal pancreas is a potential source for progenitor cells to generate endocrine β-cells for
treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas …
treating type 1 diabetes. However, it remains unclear whether young (1-week-old) pancreas …
In vitro colony assays for characterizing tri-potent progenitor cells isolated from the adult murine pancreas
JR Tremblay, JM LeBon, A Luo… - Journal of …, 2016 - pmc.ncbi.nlm.nih.gov
Stem and progenitor cells from the adult pancreas could be a potential source of therapeutic
beta-like cells for treating patients with type 1 diabetes. However, it is still unknown whether …
beta-like cells for treating patients with type 1 diabetes. However, it is still unknown whether …
A GLIS3–CD133–WNT-signaling axis regulates the self-renewal of adult murine pancreatic progenitor-like cells in colonies and organoids
JR Tremblay, K Lopez, HT Ku - Journal of Biological Chemistry, 2019 - ASBMB
The existence and regenerative potential of resident stem and progenitor cells in the adult
pancreas are controversial topics. A question that has been only minimally addressed is the …
pancreas are controversial topics. A question that has been only minimally addressed is the …
Liver and pancreas
MLZ Dagli, LM Chaible, K Steiger - Pathology of Genetically …, 2021 - Wiley Online Library
The liver is a central organ for detoxification of xenobiotics and other important functions.
This chapter describes the existing models for hepatic and pancreatic human diseases and …
This chapter describes the existing models for hepatic and pancreatic human diseases and …
Quiescent Pancreatic Stellate Cells Serve as a Novel Producible Resource of Effective Human Islet-Like Organoids
C Ni, Z Cai, Y Chen, Y Zhou, H Wang, Q Wang… - Available at SSRN … - papers.ssrn.com
Background: The deterioration of pancreatic β-cell function is central to diabetes
pathogenesis, underscoring the necessity for cell-replacement strategies. Previously …
pathogenesis, underscoring the necessity for cell-replacement strategies. Previously …
Characterization of Ductal Progenitor-Like Cells From the Adult Human Pancreas
HN Zook - 2023 - search.proquest.com
Damage to pancreatic exocrine cells occurs during pathogenesis of pancreatic diseases,
such as pancreatitis and diabetes. A subset of adult human ductal cells exhibits progenitor …
such as pancreatitis and diabetes. A subset of adult human ductal cells exhibits progenitor …