Generative deep learning for targeted compound design

T Sousa, J Correia, V Pereira… - Journal of chemical …, 2021 - ACS Publications
In the past few years, de novo molecular design has increasingly been using generative
models from the emergent field of Deep Learning, proposing novel compounds that are …

[HTML][HTML] Enhancing preclinical drug discovery with artificial intelligence

RSK Vijayan, J Kihlberg, JB Cross, V Poongavanam - Drug discovery today, 2022 - Elsevier
Artificial intelligence (AI) is becoming an integral part of drug discovery. It has the potential to
deliver across the drug discovery and development value chain, starting from target …

Ab initio quantum chemistry with neural-network wavefunctions

J Hermann, J Spencer, K Choo, A Mezzacapo… - Nature Reviews …, 2023 - nature.com
Deep learning methods outperform human capabilities in pattern recognition and data
processing problems and now have an increasingly important role in scientific discovery. A …

Artificial intelligence in drug discovery: applications and techniques

J Deng, Z Yang, I Ojima, D Samaras… - Briefings in …, 2022 - academic.oup.com
Artificial intelligence (AI) has been transforming the practice of drug discovery in the past
decade. Various AI techniques have been used in many drug discovery applications, such …

From turing to transformers: A comprehensive review and tutorial on the evolution and applications of generative transformer models

EY Zhang, AD Cheok, Z Pan, J Cai, Y Yan - Sci, 2023 - mdpi.com
In recent years, generative transformers have become increasingly prevalent in the field of
artificial intelligence, especially within the scope of natural language processing. This paper …

Machine learning in drug design: Use of artificial intelligence to explore the chemical structure–biological activity relationship

M Staszak, K Staszak, K Wieszczycka… - Wiley …, 2022 - Wiley Online Library
The paper presents a comprehensive overview of the use of artificial intelligence (AI)
systems in drug design. Neural networks, which are one of the systems employed in AI, are …

Generative AI for designing and validating easily synthesizable and structurally novel antibiotics

K Swanson, G Liu, DB Catacutan, A Arnold… - Nature Machine …, 2024 - nature.com
The rise of pan-resistant bacteria is creating an urgent need for structurally novel antibiotics.
Artificial intelligence methods can discover new antibiotics, but existing methods have …

A review on generative adversarial networks for image generation

VLT De Souza, BAD Marques, HC Batagelo… - Computers & …, 2023 - Elsevier
Abstract Generative Adversarial Networks (GANs) are a type of deep learning architecture
that uses two networks namely a generator and a discriminator that, by competing against …

Machine learning designs non-hemolytic antimicrobial peptides

A Capecchi, X Cai, H Personne, T Köhler… - Chemical …, 2021 - pubs.rsc.org
Machine learning (ML) consists of the recognition of patterns from training data and offers
the opportunity to exploit large structure–activity databases for drug design. In the area of …

Adsorption enthalpies for catalysis modeling through machine-learned descriptors

M Andersen, K Reuter - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Heterogeneous catalysts are rather complex materials that come in many
classes (eg, metals, oxides, carbides) and shapes. At the same time, the interaction of the …