Immunosuppressive signaling pathways as targeted cancer therapies

BP Setlai, R Hull, M Bida, C Durandt, TV Mulaudzi… - Biomedicines, 2022 - mdpi.com
Immune response has been shown to play an important role in defining patient prognosis
and response to cancer treatment. Tumor-induced immunosuppression encouraged the …

[HTML][HTML] EMAST Type of Microsatellite Instability—A Distinct Entity or Blurred Overlap between Stable and MSI Tumors

K Vuković Đerfi, A Salar, T Cacev, S Kapitanović - Genes, 2023 - mdpi.com
Microsatellite instability (MSI) represents an accumulation of frameshifts in short tandem
repeats, microsatellites, across the genome due to defective DNA mismatch repair (dMMR) …

A novel thinking: DDR axis refines the classification of ccRCC with distinctive prognosis, multi omics landscape and management strategy

A Jiang, J Song, X Fang, Y Fang, Z Wang… - Frontiers in Public …, 2022 - frontiersin.org
Background DNA damage response and repair (DDR) related signatures play an important
role in maintaining genome stability and other biological processes. It also affects the …

Organoids and metastatic orthotopic mouse model for mismatch repair-deficient colorectal cancer

Y Song, TD Kerr, C Sanders, L Dai, SS Baxter… - Frontiers in …, 2023 - frontiersin.org
Background Genome integrity is essential for the survival of an organism. DNA mismatch
repair (MMR) genes (eg, MLH1, MSH2, MSH6, and PMS2) play a critical role in the DNA …

Unraveling the complex interconnection between specific inflammatory signaling pathways and mechanisms involved in HIV-associated colorectal oncogenesis

BP Damane, TV Mulaudzi, SS Kader, P Naidoo… - Cancers, 2023 - mdpi.com
Simple Summary Despite the reduced death rate that comes with improved HIV treatment,
chances of develo** cancers in HIV infected individuals remains high. The main culprit …

[HTML][HTML] Mismatch repair status characterization in oncologic pathology: taking stock of the real-world possibilities

R Piciotti, K Venetis, E Sajjadi, N Fusco - Journal of Molecular Pathology, 2021 - mdpi.com
The mismatch repair (MMR) system has a key role in supporting the DNA polymerase
proofreading function and in maintaining genome stability. Alterations in the MMR genes are …

[HTML][HTML] Mesothelioma mouse models with mixed genomic states of chromosome and microsatellite instability

Y Song, SS Baxter, L Dai, C Sanders, S Burkett… - Cancers, 2022 - mdpi.com
Simple Summary Only a limited number of murine mesothelioma cell lines have been
developed to date. We sought to expand this number and to characterize the models in …

[PDF][PDF] Immunosuppressive signaling pathways as targeted cancer therapies. Biomedicines. 2022; 10: 682

BP Setlai, R Hull, M Bida, C Durandt, TV Mulaudzi… - 2022 - academia.edu
Immune response has been shown to play an important role in defining patient prognosis
and response to cancer treatment. Tumor-induced immunosuppression encouraged the …

Characterising the evolutionary dynamics of hypermutated tumours using single-cell sequencing

M Kalyva - 2024 - repository.cam.ac.uk
DNA mismatch repair deficiency (MMRD) is caused by the inactivation of the mismatch
repair pathway, which corrects DNA replication-associated errors. MMRD results in an …

[PDF][PDF] Unraveling the Complex Interconnection Between Specific Inflammatory Signaling Pathways and Mechanisms Involved in HIV-Associated Colorectal …

BP Damane, TV Mulaudzi, SS Kader, P Naidoo… - 2023 - researchgate.net
The advancement of HIV treatment has led to increased life expectancy. However, people
living with HIV (PLWH) are at a higher risk of develo** colorectal cancers. Chronic …