Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …

The collective migration of cells as a cohesive group is a hallmark of the tissue remodelling
events that underlie embryonic morphogenesis, wound repair and cancer invasion. In such …

Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core
of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins …

Collective cell movement occurs when two or more cells that retain their cell-cell junctions
move together across a two-dimensional (2D) layer of extracellular matrix (ECM) or through …

Inflammatory bowel diseases (IBD) such as Crohn's disease (CD) and Ulcerative colitis (UC)
have a complex and multifactorial pathogenesis which is incompletely understood. A typical …

Diseases at the molecular level are complex and patient dependent, necessitating
development of strategies that enable precision treatment to optimize clinical outcomes …

Adherens junctions, which are intercellular adhesive complexes that are crucial for
maintaining epithelial homeostasis, are downregulated in many cancers to promote tumour …

BACKGROUND & AIMS: Expression of the tight junction protein claudin-1 is dysregulated in
colon tumors and associates with their progression. Up-regulation of claudin-1 reduces …

Much evidence now attests to the importance of desmosomes and their constituents in
cancer. Alterations in the expression of desmosomal components could contribute to the …

Tumors are not merely cancerous cells that undergo mindless proliferation. Rather, they are
highly organized and interconnected organ systems. Tumor cells reside in complex …