Abstract Latent Epstein–Barr virus (EBV) infection has a substantial role in causing many
human disorders. The persistence of these viral genomes in all malignant cells, yet with the …

Within weeks of the first report of acquired immunodeficiency syndrome (AIDS) in 1981, it
was observed that these patients often had Kaposi sarcoma (KS), a hitherto rarely seen skin …

Simple Summary Epstein–Barr virus (EBV) was first isolated in 1964 and has since become
an important human tumor virus. With an estimated 90% of the human population infected …

Epstein-Barr virus latent membrane protein 1 (LMP1) is expressed in multiple human
malignancies, including nasopharyngeal carcinoma and Hodgkin and immunosuppression …

Worldwide, one fifth of cancers in the population are associated with viral infections. Among
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …

Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma (BL) and immunosuppression-
related lymphomas. These B cell malignancies arise by distinct transformation pathways and …

Epstein–Barr virus (EBV) was first discovered in 1964, and was the first known human tumor
virus now shown to be associated with a vast number of human diseases. Numerous studies …

Highlights•EBV is an oncogenic gammaherpesvirus that transforms human primary B-
cells.•EBV encoded transcription factors assemble at primed enhancers to activate cell …

Epstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell
lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV …

Epstein-Barr virus (EBV) infection of human primary resting B lymphocytes (RBLs) leads to
the establishment of lymphoblastoid cell lines (LCLs) that can grow indefinitely in vitro. EBV …