Overview of iron metabolism in health and disease
Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …
Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines
LT Goodnough, A Maniatis, P Earnshaw… - British journal of …, 2011 - academic.oup.com
Previously undiagnosed anaemia is common in elective orthopaedic surgical patients and is
associated with increased likelihood of blood transfusion and increased perioperative …
associated with increased likelihood of blood transfusion and increased perioperative …
A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
Background Anemia is associated with an increased risk of cardiovascular and renal events
among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa …
among patients with type 2 diabetes and chronic kidney disease. Although darbepoetin alfa …
Physiology and pharmacology of erythropoietin
W Jelkmann - Transfusion Medicine and Hemotherapy, 2013 - karger.com
Human erythropoietin (Epo) is a 30.4 kDa glycoprotein hormone composed of a single 165
amino acid residues chain to which four glycans are attached. The kidneys are the primary …
amino acid residues chain to which four glycans are attached. The kidneys are the primary …
Cellular senescence, vascular disease, and aging: part 2 of a 2-part review: clinical vascular disease in the elderly
JC Kovacic, P Moreno, EG Nabel, V Hachinski… - Circulation, 2011 - Am Heart Assoc
The increasing prevalence of older-age people in our society represents the culmination of
centuries of medical, scientific, and social endeavors. At least in Western society, now …
centuries of medical, scientific, and social endeavors. At least in Western society, now …
Alternatives to blood transfusion
DR Spahn, LT Goodnough - The Lancet, 2013 - thelancet.com
The use of alternatives to allogeneic blood continues to rest on the principles that blood
transfusions have inherent risks, associated costs, and affect the blood inventory available …
transfusions have inherent risks, associated costs, and affect the blood inventory available …
Meta-analysis: erythropoiesis-stimulating agents in patients with chronic kidney disease
SC Palmer, SD Navaneethan, JC Craig… - Annals of internal …, 2010 - acpjournals.org
Background: Previous meta-analyses suggest that treatment with erythropoiesis-stimulating
agents (ESAs) in chronic kidney disease (CKD) increases the risk for death. Additional …
agents (ESAs) in chronic kidney disease (CKD) increases the risk for death. Additional …
Erythropoietin or darbepoetin for patients with cancer
T Tonia, A Mettler, N Robert… - Cochrane database …, 2012 - cochranelibrary.com
Background Anaemia associated with cancer and cancer therapy is an important clinical
factor in the treatment of malignant diseases. Therapeutic alternatives are recombinant …
factor in the treatment of malignant diseases. Therapeutic alternatives are recombinant …
Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation–associated thrombotic microangiopathy
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a challenging
diagnosis after hematopoietic stem cell transplantation. Although endothelial injury …
diagnosis after hematopoietic stem cell transplantation. Although endothelial injury …
Cancer-and chemotherapy-induced anemia
Anemia is prevalent in 30% to 90% of patients with cancer. Anemia can be corrected
through either treating the underlying cause or providing supportive care through transfusion …
through either treating the underlying cause or providing supportive care through transfusion …