Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …

Abstract Mitochondria contain about 1,000–1,500 proteins that fulfil multiple functions.
Mitochondrial proteins originate from two genomes: mitochondrial and nuclear. Hence …

Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

The 70-kDa heat shock proteins (Hsp70s) are ubiquitous molecular chaperones that act in a
large variety of cellular protein folding and remodelling processes. They function virtually at …

Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …

Doxorubicin (DOX) is a chemotherapeutic drug that is utilized for solid tumors and
hematologic malignancies, but its clinical application is hampered by life-threatening …

Contrary to the long-held view that most humans harbour only identical mitochondrial
genomes, deep resequencing has uncovered unanticipated extreme genetic variation within …