The histone acetyltransferases CBP and p300, often referred to as CBP/p300 due to their
sequence homology and functional overlap and co-operation, are emerging as critical …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response
to a wide variety of signals, yet target gene transcription is only increased in a subset of …

Inactivating mutations of the CREBBP acetyltransferase are highly frequent in diffuse large B-
cell lymphoma (DLBCL) and follicular lymphoma (FL), the two most common germinal center …

Glucose homeostasis is regulated systemically by hormones such as insulin and glucagon,
and at the cellular level by energy status. Glucagon enhances glucose output from the liver …

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both
memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes …

The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …

Primary mediastinal large B-cell lymphoma (PMBL) represents a clinically and
pathologically distinct subtype of large B-cell lymphomas. Furthermore, molecular studies …

The transcriptional coactivators CREB binding protein (CBP) and p300 are key regulators of
RNA polymerase II-mediated transcription. Genetic alterations in the genes encoding these …

MicroRNAs (miRNAs) are a recently identified class of epigenetic elements consisting of
small noncoding RNAs that bind to the 3′ untranslated region of mRNAs and down …