Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and
disease risks independent of chronological age. It may serve as a useful biomarker of …

Aging is a significant risk factor for various human disorders, and DNA methylation clocks
have emerged as powerful tools for estimating biological age and predicting health‐related …

The prevalence of obesity has dramatically increased worldwide over the past decades.
Aging-related chronic conditions, such as type 2 diabetes and cardiovascular disease, are …

Abstract Background Metabolic syndrome (MetS) is associated with premature aging, but
whether this association is driven by genetic or lifestyle factors remains unclear. Methods …

Abstract The CARDIA (Coronary Artery Risk Development in Young Adults) study began in
1985 to 1986 with enrollment of 5,115 Black or White men and women ages 18 to 30 years …

Background: Cardiovascular health (CVH) from young adulthood is strongly associated with
an individual's future risk of cardiovascular disease (CVD) and total mortality. Defining …

Background: Hypertension is common in older individuals and is a major risk factor for
cardiovascular disease. Blood DNA methylation profiles have been used to derive metrics of …

Despite impressive efforts invested in epigenetic research in the last 50 years, clinical
applications are still lacking. Only a few university hospital centers currently use epigenetic …