Many disciplines, from human genetics and oncology to plant breeding, microbiology and
virology, commonly face the challenge of analyzing rapidly increasing numbers of genomes …

We describe the most common internal and external sources and types of contamination
encountered in viral metagenomic studies and discuss their negative impact on sequencing …

In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra
Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra …

MOSAIK is a stable, sensitive and open-source program for map** second and third-
generation sequencing reads to a reference genome. Uniquely among current map** …

Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid
glial neoplasms of the thalamus or brainstem that typically arise in young children and are …

Background Extensive genetic diversity in viral populations within infected hosts and the
divergence of variants from existing reference genomes impede the analysis of deep viral …

Abstract Background: Oxford Nanopore Technologies Ltd (Oxford, UK) have recently
commercialized MinION, a small single-molecule nanopore sequencer, that offers the …

We have developed a robust RNA sequencing method for generating complete de novo
assemblies with intra-host variant calls of Lassa and Ebola virus genomes in clinical and …

Studying the evolution of viruses and their molecular epidemiology relies on accurate viral
sequence data, so that small differences between similar viruses can be meaningfully …

Human respiratory syncytial virus (RSV) is associated with severe childhood respiratory
infections. A clear description of local RSV molecular epidemiology, evolution, and …