Cellular stress induced by the abnormal accumulation of unfolded or misfolded proteins at
the endoplasmic reticulum (ER) is emerging as a possible driver of human diseases …

The deposition of chemical modifications into RNA is a crucial regulator of temporal and
spatial gene expression programs during development. Accordingly, altered RNA …

Cortical organoids are self-organizing three-dimensional cultures that model features of the
develo** human cerebral cortex,. However, the fidelity of organoid models remains …

Reprogramming of mRNA translation has a key role in cancer development and drug
resistance. However, the molecular mechanisms that are involved in this process remain …

Cancer genomics has revealed many genes and core molecular processes that contribute to
human malignancies, but the genetic and molecular bases of many rare cancers remains …

A brain organoid is a self-organizing three-dimensional tissue derived from human
embryonic stem cells or pluripotent stem cells and is able to simulate the architecture and …

Sustaining neuronal proteostasis during the course of our life is a central aspect required for
brain function. The dynamic nature of synaptic composition and abundance is a requisite to …

Galloway–Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by
the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain …

Global protein translation as well as translation at the codon level can be regulated by tRNA
modifications. In eukaryotes, levels of tRNA queuosinylation reflect the bioavailability of the …

Owing to recent medical and technological advances in neonatal care, infants born
extremely premature have increased survival rates,. After birth, these infants are at high risk …