[HTML][HTML] Ageing–oxidative stress, PTMs and disease

T Ebert, N Tran, L Schurgers, P Stenvinkel… - Molecular aspects of …, 2022 - Elsevier
Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …

Single-cell analyses of aging, inflammation and senescence

B Uyar, D Palmer, A Kowald, HM Escobar… - Ageing research …, 2020 - Elsevier
Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and
are increasingly used to track organisms along their life-course. This allows investigation …

Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

G Brunetti, G Di Rosa, M Scuto, M Leri… - International journal of …, 2020 - mdpi.com
Numerous studies highlighted the beneficial effects of the Mediterranean diet (MD) in
maintaining health, especially during ageing. Even neurodegeneration, which is part of the …

Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models

G Di Rosa, G Brunetti, M Scuto… - International Journal of …, 2020 - mdpi.com
Parkinson's disease (PD) is the second most prevalent late-age onset neurodegenerative
disorder, affecting 1% of the population after the age of about 60 years old and 4% of those …

[HTML][HTML] Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Q Yang, X Wei, B Deng, Z Chang, D **, Y Huang… - Neurobiology of …, 2022 - Elsevier
Cerebral small vessel disease (CSVD) is a generic term used for intracranial vascular
disorders caused by the structural changes of cerebral microvessels, including the small …

Ranking biomarkers of aging by citation profiling and effort scoring

A Hartmann, C Hartmann, R Secci, A Hermann… - Frontiers in …, 2021 - frontiersin.org
Aging affects most living organisms and includes the processes that reduce health and
survival. The chronological and the biological age of individuals can differ remarkably, and …

Ligusticum chuanxiong Hort as a medicinal and edible plant foods: Antioxidant, anti-aging and neuroprotective properties in Caenorhabditis elegans

Y Qin, F Chen, Z Tang, H Ren, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Ligusticum chuanxiong Hort.(CX) is a medicinal and edible plant including a variety of active
substances, which may be an available resource for the treatment of related diseases. To …

Are we ill because we age?

T Fulop, A Larbi, A Khalil, AA Cohen… - Frontiers in …, 2019 - frontiersin.org
Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an
increasingly serious health and socioeconomic concern for modern societies. Science has …

Improvements to healthspan through environmental enrichment and lifestyle interventions: where are we now?

NJ Queen, QN Hassan, L Cao - Frontiers in Neuroscience, 2020 - frontiersin.org
Environmental enrichment (EE) is an experimental paradigm that is used to explore how a
complex, stimulating environment can impact overall health. In laboratory animal …

Vascular aging detected by peripheral endothelial dysfunction is associated with ecg‐derived physiological aging

T Toya, A Ahmad, Z Attia, M Cohen‐Shelly… - Journal of the …, 2021 - Am Heart Assoc
Background An artificial intelligence algorithm that detects age using the 12‐lead ECG has
been suggested to signal “physiologic age.” This study aimed to investigate the association …