Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

Highlights•The apicoplast critically participates in metabolism of disease-causing
apicomplexans.•T. gondii overcomes loss of apicoplast-resident pathways through uptake of …

In 1981 I established kingdom Chromista, distinguished from Plantae because of its more
complex chloroplast-associated membrane topology and rigid tubular multipartite ciliary …

Transient lysosomal damage after infection with cytosolic pathogens or silica crystals uptake
results in protease leakage. Whether limited leakage of lysosomal contents into the cytosol …

Tuberculosis, caused by the intracellular pathogen Mycobacterium tuberculosis, remains the
world's deadliest infectious disease. Sterilizing chemotherapy requires at least 6 months of …

The apicoplast is an essential organelle for the viability of apicomplexan parasites
Plasmodium falciparum or Toxoplasma gondii, which has been proposed as a suitable drug …

Background Plasmodium falciparum is the pathogen responsible for the most devastating
form of human malaria. As it replicates asexually in the erythrocytes of its human host, the …

Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine
lipids from both host cell scavenging and de novo synthesis to maintain parasite …

Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast,
which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) …

Iron‑sulfur cluster are ubiquitous and ancient protein cofactors that support a wide array of
essential cellular functions. In eukaryotes, their assembly requires specific and dedicated …