The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia
BC Bastian - Annual Review of Pathology: Mechanisms of …, 2014 - annualreviews.org
Melanomas comprise multiple biologically distinct categories, which differ in cell of origin,
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …
Melanocytic nevi and melanoma: unraveling a complex relationship
WE Damsky, M Bosenberg - Oncogene, 2017 - nature.com
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
AA Al Olama, Z Kote-Jarai, SI Berndt, DV Conti… - Nature …, 2014 - nature.com
Genome-wide association studies (GWAS) have identified 76 variants associated with
prostate cancer risk predominantly in populations of European ancestry. To identify …
prostate cancer risk predominantly in populations of European ancestry. To identify …
Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility
Most genetic susceptibility to cutaneous melanoma remains to be discovered. Meta-analysis
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
genome-wide association study (GWAS) of 36,760 cases of melanoma (67% newly …
Genome-wide association study identifies five new breast cancer susceptibility loci
Breast cancer is the most common cancer in women in developed countries. To identify
common breast cancer susceptibility alleles, we conducted a genome-wide association …
common breast cancer susceptibility alleles, we conducted a genome-wide association …
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
So far, two genes associated with familial melanoma have been identified, accounting for a
minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of …
minority of genetic risk in families. Mutations in CDKN2A account for approximately 40% of …
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Y Lu, FR Day, S Gustafsson, ML Buchkovich… - Nature …, 2016 - nature.com
To increase our understanding of the genetic basis of adiposity and its links to
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …
cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of …
Melanoma genetics
Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of develo** melanoma …
positive family history is associated with an increased risk of develo** melanoma …
Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
A Congrains, K Kamide, R Oguro, O Yasuda, K Miyata… - Atherosclerosis, 2012 - Elsevier
Genome-wide association studies (GWAS) have identified genetic variants contributing to
the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD …
the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The CVD …
Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma
Thirteen common susceptibility loci have been reproducibly associated with cutaneous
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …
malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis …