Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

Simple Summary Many signaling pathways are overactive in breast cancer, and among
them is the STAT3 signaling pathway. STAT3 is activated by secreted factors within the …

The adipocyte-released hormone-like cytokine/adipokine leptin behaves differently in
obesity compared to its functions in the normal healthy state. In obese individuals, elevated …

Preclinical data support a role for the IL-6/JAK2/STAT3 signaling pathway in breast cancer.
Ruxolitinib is an orally bioavailable receptor tyrosine inhibitor targeting JAK1 and JAK2. We …

Once considered a problem of Western nations, obesity (body mass index≥ 30 kg/m 2) has
rapidly increased since the 1970s to become a major threat to world health. Since 1970, the …

Studies investigating the potential link between adult pre-menopausal obesity [as measured
by body mass index (BMI)] and triple-negative breast cancer have been inconsistent. Recent …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

Characterizing the ontologies of genes directly regulated by a transcription factor (TF), can
help to elucidate the TF's biological role. Previously, we developed a widely used method …

Breast cancer (BC) is one of the most common cancers in women. TNBC (Triple-negative
breast cancer) has limited treatment options and still lacks viable molecular targets, leading …

Chemoresistance is one of the major causes of therapeutic failure in breast cancer patients.
In this study, the mechanism of chemoresistance in human triple‐negative breast cancer …