In this opinion, we highlight agent-based modeling as a key tool for exploration of cell–cell
and cell–environment interactions that drive cancer progression, therapeutic resistance, and …

Simple Summary Tumor heterogeneity promotes the development of drug resistance in
cancer. HDAC inhibitors modulate several processes that contribute to intra-tumoral …

Computational models are not just appealing because they can simulate and predict the
development of biological phenomena across multiple spatial and temporal scales, but also …

Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of
treatment resistant disease. Defining how, when and where myeloma cell intrinsic and …

The water-selective channel protein aquaporin-4 (AQP4) contributes to the migration and
proliferation of gliomas, and to their resistance to therapy. Here we show, in glioma cell …

Oncolytic viruses (OVs) are emerging cancer immunotherapy. Despite notable successes in
the treatment of some tumors, OV therapy for central nervous system cancers has failed to …

Background Hepatocellular carcinoma (HCC) is the most common form of primary liver
cancer and is the third-leading cause of cancer-related death worldwide. Most patients with …

Glioblastoma is the most common and deadly primary brain tumor in adults. All glioblastoma
patients receiving standard-of-care surgery-radiotherapy-chemotherapy (ie, temozolomide …

Photodynamic therapy (PDT) has recently gained attention as an alternative treatment of
malignant gliomas. Glioblastoma (GBM) is the most prevalent within tumors of the central …

Tumors consist of different genotypically distinct subpopulations—or subclones—of cells.
These subclones can influence neighboring clones in a process called “clonal interaction.” …