Chiral seven-membered ring systems such as seven-membered carbocycles and
heterocycles are widely found in natural products and pharmaceuticals. Therefore, the …

Chiral Phosphoric Acids (CPAs) are a highly versatile class of Brønsted acid organocatalysts
that have witnessed a surge in their use in asymmetric synthesis in recent years. Various …

Abstract The regio‐and enantioselective (3+ 3) cycloaddition of nitrones with 2‐
indolylmethanols was accomplished by the cooperative catalysis of hexafluoroisopropanol …

A Ru‐catalyzed direct asymmetric reductive amination of ortho‐OH‐substituted diaryl and
sterically hindered ketones with ammonium salts is reported. This method represents a …

A practical method for the synthesis of α‐chiral amines by alkylation of amines with alcohols
in the absence of any transition‐metal catalysts has been developed. Under the co‐catalysis …

Chiral diarylmethylamines (DAMA) are important structural motifs widely present in
pharmaceuticals, natural products, and chiral ligands. Herein, we reported a highly …

Abstract Palladium‐catalyzed asymmetric [4+ 5] annulation of ortho‐quinone methides (o‐
QMs) with substituted vinylethylene carbonates (VECs) is described for the first time, giving a …

A Brønsted acid-catalyzed C3-alkylation of indolizines has been established with different
electrophiles such as ortho-hydroxybenzyl alcohols, other precursors of para-quinone …

Carboranyl amines are distinct from typical organic amines. Due to the electronic influence
of the carborane cage, they have low nucleophilicity and are reluctant to alkylate. Moreover …

Using a statistical Z-score methodology, enantiomeric excess (ee) data from our historical
high-throughput classical chiral resolution screens were analyzed. In total, 19 of the screens …