Lyme disease in humans
Lyme disease (Lyme borreliosis) is a tick-borne, zoonosis of adults and children caused by
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …
genospecies of the Borrelia burgdorferi sensu lato complex. The ailment, widespread …
Lyme disease pathogenesis
Lyme disease Borrelia are obligately parasitic, tick-transmitted, invasive, persistent bacterial
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …
pathogens that cause disease in humans and non-reservoir vertebrates primarily through …
The evolving story of Borrelia burgdorferi sensu lato transmission in Europe
Beside mosquitoes, ticks are well-known vectors of different human pathogens. In the
Northern Hemisphere, Lyme borreliosis (Eurasia, LB) or Lyme disease (North America, LD) …
Northern Hemisphere, Lyme borreliosis (Eurasia, LB) or Lyme disease (North America, LD) …
Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex
Pathogens that traffic in blood, lymphatics, or interstitial fluids must adopt strategies to evade
innate immune defenses, notably the complement system. Through recruitment of host …
innate immune defenses, notably the complement system. Through recruitment of host …
Complement evasion by Lyme disease spirochetes
JT Skare, BL Garcia - Trends in microbiology, 2020 - cell.com
The complement system is an ancient arm of the innate immune system that plays important
roles in pathogen recognition and elimination. Upon activation by microbes, complement …
roles in pathogen recognition and elimination. Upon activation by microbes, complement …
Borrelia burgdorferi Manipulates Innate and Adaptive Immunity to Establish Persistence in Rodent Reservoir Hosts
KE Tracy, N Baumgarth - Frontiers in immunology, 2017 - frontiersin.org
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent
infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild …
infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild …
The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
MJ Caimano, AM Groshong, A Belperron… - Frontiers in …, 2019 - frontiersin.org
Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …
pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting …
Pathogenicity and virulence of Borrelia burgdorferi
M Strnad, N Rudenko, ROM Rego - Virulence, 2023 - Taylor & Francis
Infection with Borrelia burgdorferi often triggers pathophysiologic perturbations that are
further augmented by the inflammatory responses of the host, resulting in the severe clinical …
further augmented by the inflammatory responses of the host, resulting in the severe clinical …
Strain-specific joint invasion and colonization by Lyme disease spirochetes is promoted by outer surface protein C
YP Lin, X Tan, JA Caine, M Castellanos… - PLoS …, 2020 - journals.plos.org
Lyme disease, caused by Borrelia burgdorferi, B. afzelii and B. garinii, is a chronic, multi-
systemic infection and the spectrum of tissues affected can vary with the Lyme disease …
systemic infection and the spectrum of tissues affected can vary with the Lyme disease …
Comprehensive spatial analysis of the Borrelia burgdorferi lipoproteome reveals a compartmentalization bias toward the bacterial surface
ABSTRACT The Lyme disease spirochete Borrelia burgdorferi is unique among bacteria in
its large number of lipoproteins that are encoded by a small, exceptionally fragmented, and …
its large number of lipoproteins that are encoded by a small, exceptionally fragmented, and …