In the recent past the standard treatment of kala‐azar involved the use of pentavalent
antimonials Sb (V). Because of progressive rise in treatment failure to Sb (V) was limited its …

Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Experimental visceral leishmaniasis (VL) caused by infection with Leishmania donovani
results in the development of organ‐specific immunity in the two main target tissues of …

ABSTRACT Interleukin-10 (IL-10) is thought to promote intracellular infection, including
human visceral leishmaniasis, by disabling Th1 cell-type responses and/or deactivating …

Visceral leishmaniaisis (kala-azar) is a disseminated protozoal infection, transmitted by
sandffy bite, in which macrophages of the liver, spleen, and bone marrow are preferentially …

Key antigens of Leishmania species identified in the context of host responses in
Leishmania‐exposed individuals from disease‐endemic areas were prioritized for the …

Leishmania mexicana mutants lacking cysteine proteinase genes cpa (Δcpa), cpb (Δcpb), or
both cpa and cpb (Δcpa/cpb) have been generated by targeted gene disruption. Δcpa …

In experimental visceral leishmaniasis in normal mice (BALB/c, C57BL/6) acquired
resistance to Leishmania donovani, a protozoan which targets tissue macrophages …

The Leishmania-derived recombinant polyprotein Leish-111f or its three component
proteins, thiol-specific antioxidant (TSA), Leishmania major stress-inducible protein 1 …

Pentavalent antimony complexes, such as sodium stibogluconate and sodium antimony
gluconate (SAG), are still the first choice for chemotherapy against various forms of …