Transition metal complexes and photodynamic therapy from a tumor-centered approach: challenges, opportunities, and highlights from the development of TLD1433
Transition metal complexes are of increasing interest as photosensitizers in photodynamic
therapy (PDT) and, more recently, for photochemotherapy (PCT). In recent years, Ru (II) …
therapy (PDT) and, more recently, for photochemotherapy (PCT). In recent years, Ru (II) …
From bench to bedside–preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis (1H-indazole) ruthenate (III)](KP1019 or …
CG Hartinger, S Zorbas-Seifried, MA Jakupec… - Journal of inorganic …, 2006 - Elsevier
Indazolium trans-[tetrachlorobis (1H-indazole) ruthenate (III)](KP1019 or FFC14A) is just the
second ruthenium-based anticancer agent after NAMI-A which was developed to the stage …
second ruthenium-based anticancer agent after NAMI-A which was developed to the stage …
NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application
R Trondl, P Heffeter, CR Kowol, MA Jakupec… - Chemical …, 2014 - pubs.rsc.org
NKP-1339 is the first-in-class ruthenium-based anticancer drug in clinical development
against solid cancer and has recently been studied successfully in a phase I clinical trial …
against solid cancer and has recently been studied successfully in a phase I clinical trial …
Combination of Ru (II) complexes and light: new frontiers in cancer therapy
The synergistic action of light, oxygen and a photosensitizer (PS) has found applications for
decades in medicine under the name of photodynamic therapy (PDT) for the treatment of …
decades in medicine under the name of photodynamic therapy (PDT) for the treatment of …
KP1019, a new redox‐active anticancer agent–Preclinical development and results of a clinical phase I study in tumor patients
CG Hartinger, MA Jakupec… - Chemistry & …, 2008 - Wiley Online Library
The promising drug candidate indazolium trans‐[tetrachlorobis (1H‐indazole) ruthenate
(III)](KP1019) is the second Ru‐based anticancer agent to enter clinical trials. In this review …
(III)](KP1019) is the second Ru‐based anticancer agent to enter clinical trials. In this review …
The development of RAPTA compounds for the treatment of tumors
Abstract Ruthenium (II)-arene RAPTA-type compounds have been extensively explored for
their medicinal properties. Herein a comprehensive review of this class of compounds is …
their medicinal properties. Herein a comprehensive review of this class of compounds is …
Thirty years of the drug candidate NAMI‐A and the myths in the field of ruthenium anticancer compounds: a personal perspective
E Alessio - European Journal of Inorganic Chemistry, 2017 - Wiley Online Library
As anticipated in the title, this contribution is basically divided into two, strictly connected,
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
parts. The first is a personal overview of the ruthenium drug candidate NAMI‐A, almost 30 …
Redox activation of metal-based prodrugs as a strategy for drug delivery
N Graf, SJ Lippard - Advanced drug delivery reviews, 2012 - Elsevier
This review provides an overview of metal-based anticancer drugs and drug candidates. In
particular, we focus on metal complexes that can be activated in the reducing environment of …
particular, we focus on metal complexes that can be activated in the reducing environment of …
Ruthenium-based chemotherapeutics: are they ready for prime time?
Since the discovery of cis-platinum, many transition metal complexes have been
synthesized and assayed for antineoplastic activity. In recent years, ruthenium-based …
synthesized and assayed for antineoplastic activity. In recent years, ruthenium-based …
Non platinum metal complexes as anti‐cancer drugs
I Ott, R Gust - Archiv der Pharmazie: An International Journal …, 2007 - Wiley Online Library
The development of metal complexes with platinum central atoms such as cisplatin or
carboplatin had an enormous impact on current cancer chemotherapy. However, the …
carboplatin had an enormous impact on current cancer chemotherapy. However, the …