The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
Nuclear speckles–a driving force in gene expression
GP Faber, S Nadav-Eliyahu… - Journal of cell …, 2022 - journals.biologists.com
Nuclear speckles are dynamic membraneless bodies located in the cell nucleus. They
harbor RNAs and proteins, many of which are splicing factors, that together display complex …
harbor RNAs and proteins, many of which are splicing factors, that together display complex …
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis
While SARS-CoV-2 continues to adapt for human infection and transmission, genetic
variation outside of the spike gene remains largely unexplored. This study investigates a …
variation outside of the spike gene remains largely unexplored. This study investigates a …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition
X Liu, A Verma, G Garcia Jr… - Proceedings of the …, 2021 - National Acad Sciences
The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …
19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections …
[HTML][HTML] Signaling mechanisms of SARS-CoV-2 Nucleocapsid protein in viral infection, cell death and inflammation
W Wang, J Chen, X Yu, HY Lan - International journal of biological …, 2022 - ncbi.nlm.nih.gov
COVID-19 which is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …
2) has posed a worldwide pandemic and a major global public health threat. SARS-CoV-2 …
Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
SM Cascarina, ED Ross - Journal of Biological Chemistry, 2022 - ASBMB
In response to the recent SARS-CoV-2 pandemic, a number of labs across the world have
reallocated their time and resources to better our understanding of the virus. For some …
reallocated their time and resources to better our understanding of the virus. For some …
[HTML][HTML] The mechanism of SARS-CoV-2 nucleocapsid protein recognition by the human 14-3-3 proteins
KV Tugaeva, DEDP Hawkins, JLR Smith… - Journal of Molecular …, 2021 - Elsevier
The coronavirus nucleocapsid protein (N) controls viral genome packaging and contains
numerous phosphorylation sites located within unstructured regions. Binding of …
numerous phosphorylation sites located within unstructured regions. Binding of …
Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures
Nucleocapsid protein (N-protein) is required for multiple steps in betacoronaviruses
replication. SARS-CoV-2-N-protein condenses with specific viral RNAs at particular …
replication. SARS-CoV-2-N-protein condenses with specific viral RNAs at particular …
Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation
The nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 is
responsible for compaction of the∼ 30-kb RNA genome in the∼ 90-nm virion. Previous …
responsible for compaction of the∼ 30-kb RNA genome in the∼ 90-nm virion. Previous …