Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …

The rise of the “Top Down” method in the field of mass spectrometry-based proteomics has
ushered in a new age of promise and challenge for the characterization and identification of …

The correlation between mRNA and protein abundances in the cell has been reported to be
notoriously poor. Recent technological advances in the quantitative analysis of mRNA and …

Recent successes illustrate the role of mass spectrometry-based proteomics as an
indispensable tool for molecular and cellular biology and for the emerging field of systems …

A novel MS/MS-based analysis strategy using isotopomer labels, referred to as “tandem
mass tags”(TMTs), for the accurate quantification of peptides and proteins is described. The …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

We describe a largely unbiased method for rapid and large-scale proteome analysis by
multidimensional liquid chromatography, tandem mass spectrometry, and database …

Attempts to correlate protein abundance with mRNA expression levels have had variable
success. We review the results of these comparisons, focusing on yeast. In the process, we …

A full description of the human proteome relies on the challenging task of detecting mature
and changing forms of protein molecules in the body. Large-scale proteome analysis has …

The transport of fluid in and around nanometer-sized objects with at least one characteristic
dimension below 100 nm enables the occurrence of phenomena that are impossible at …