The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of
DNA cytosine deaminases provides a broad and overlap** defense against viral …

The human cytidine deaminase family of APOBEC3s (A3s) plays critical roles in both innate
immunity and the development of cancers. A3s comprise seven functionally overlap** but …

Apolipoprotein B mRNA editing enzyme catalytic subunit-like protein 3B (APOBEC3B or
A3B), as other APOBEC3 members, is a single-stranded (ss) DNA cytosine deaminase with …

The APOBEC3 family of polynucleotide cytidine deaminases has diverse roles as viral
restriction factors and oncogenic mutators. These enzymes convert cytidine to uridine in …

Abstract Background AID/APOBEC3 (A3) enzymes instigate genomic mutations that are
involved in immunity and cancer. Although they can deaminate any deoxycytidine (dC) to …

Although CRISPR/Cas9 technology has created a renaissance in genome engineering,
particularly for gene knockout generation, methods to introduce precise single base …

APOBEC3 family members are cytidine deaminases catalyzing conversion of cytidine to
uracil. Many studies have established a link between APOBEC3 expression and cancer …

The single‐stranded DNA cytosine deaminase APOBEC3B (A3B) functions in innate
immunity against viruses, but it is also strongly implicated in eliciting mutations in cancer …

Abstract APOBEC3B (A3B) is implicated in DNA mutations that facilitate tumor evolution.
Although structures of its individual N-and C-terminal domains (NTD and CTD) have been …

APOBEC3B cytosine deaminase contributes to the mutational burdens of tumors, resulting in
tumor progression and therapy resistance. Small molecule APOBEC3B inhibitors have …