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Caloric restriction
Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …
length and quality of life for over 500years. Experimental work confirming the success of this …
The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function
Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …
delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria …
[HTML][HTML] Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector
Mitochondria play a wide diversity of roles in cell physiology and have a key functional
implication in cell bioenergetics and biology of free radicals. As the main cellular source of …
implication in cell bioenergetics and biology of free radicals. As the main cellular source of …
The advanced lipoxidation end-product malondialdehyde-lysine in aging and longevity
The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …
Calorie restriction and dietary restriction mimetics: a strategy for improving healthy aging and longevity
Improvements in health care have increased human life expectancy in recent decades, and
the elderly population is thus increasing in most developed countries. Unfortunately this still …
the elderly population is thus increasing in most developed countries. Unfortunately this still …
Regulation of longevity and oxidative stress by nutritional interventions: role of methionine restriction
Comparative studies indicate that long-lived mammals have low rates of mitochondrial
reactive oxygen species production (mtROSp) and oxidative damage in their mitochondrial …
reactive oxygen species production (mtROSp) and oxidative damage in their mitochondrial …
Caloric restriction: from soup to nuts
SR Spindler - Ageing research reviews, 2010 - Elsevier
Caloric restriction (CR), reduced protein, methionine, or tryptophan diets; and reduced
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …
insulin and/or IGFI intracellular signaling can extend mean and/or maximum lifespan and …
The untapped potential of reptile biodiversity for understanding how and why animals age
The field of comparative ageing biology has greatly expanded in the past 20 years.
Longitudinal studies of populations of reptiles with a range of maximum lifespans have …
Longitudinal studies of populations of reptiles with a range of maximum lifespans have …
Intermittent fasting results in tissue-specific changes in bioenergetics and redox state
Intermittent fasting (IF) is a dietary intervention often used as an alternative to caloric
restriction (CR) and characterized by 24 hour cycles alternating ad libitum feeding and …
restriction (CR) and characterized by 24 hour cycles alternating ad libitum feeding and …
Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative …
Eighty percent dietary methionine restriction (MetR) in rodents (without calorie restriction),
like dietary restriction (DR), increases maximum longevity and strongly decreases …
like dietary restriction (DR), increases maximum longevity and strongly decreases …