Human RecQ helicases in DNA repair, recombination, and replication
DL Croteau, V Popuri, PL Opresko… - Annual review of …, 2014 - annualreviews.org
RecQ helicases are an important family of genome surveillance proteins conserved from
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
bacteria to humans. Each of the five human RecQ helicases plays critical roles in genome …
Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes
CM Rogers, RH Simmons III, GEF Thornburg… - Progress in Biophysics …, 2020 - Elsevier
DNA inter-strand crosslinks (ICLs) are dangerous lesions that can be caused by a variety of
endogenous and exogenous bifunctional compounds. Because covalently linking both …
endogenous and exogenous bifunctional compounds. Because covalently linking both …
RECQL4 promotes DNA end resection in repair of DNA double-strand breaks
The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome
stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end …
stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end …
RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex
RECQL4, a member of the RecQ helicase family, is a multifunctional participant in DNA
metabolism. RECQL4 protein participates in several functions both in the nucleus and in the …
metabolism. RECQL4 protein participates in several functions both in the nucleus and in the …
Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice
Cellular senescence refers to irreversible growth arrest of primary eukaryotic cells, a process
thought to contribute to aging-related degeneration and disease. Deficiency of RecQ …
thought to contribute to aging-related degeneration and disease. Deficiency of RecQ …
Molecular mechanisms of the RECQ4 pathogenic mutations
The human RECQ4 gene encodes an ATP-dependent DNA helicase that contains a
conserved superfamily II helicase domain located at the center of the polypeptide. RECQ4 is …
conserved superfamily II helicase domain located at the center of the polypeptide. RECQ4 is …
Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders
Abstract Rothmund-Thomson Syndrome (RTS) is a rare autosomal recessive disease which
manifests several clinical features of accelerated aging. These findings include atrophic skin …
manifests several clinical features of accelerated aging. These findings include atrophic skin …
Rothmund-Thomson syndrome: insights from new patients on the genetic variability underpinning clinical presentation and cancer outcome
EA Colombo, A Locatelli, L Cubells Sanchez… - International Journal of …, 2018 - mdpi.com
Biallelic mutations in RECQL4 gene, a caretaker of the genome, cause Rothmund-Thomson
type-II syndrome (RTS-II) and confer increased cancer risk if they damage the helicase …
type-II syndrome (RTS-II) and confer increased cancer risk if they damage the helicase …
[HTML][HTML] Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells
DNA replication is a highly coordinated process that is initiated at multiple replication origins
in eukaryotes. These origins are bound by the origin recognition complex (ORC), which …
in eukaryotes. These origins are bound by the origin recognition complex (ORC), which …
RECQ DNA helicases and osteosarcoma
The RECQ family of DNA helicases is a conserved group of enzymes that are important for
maintaining genomic integrity. In humans, there are five RECQ helicase genes, and …
maintaining genomic integrity. In humans, there are five RECQ helicase genes, and …