[PDF][PDF] Evolutionary genetics of the mitochondrial genome: insights from Drosophila

DK Dowling, JN Wolff - Genetics, 2023 - academic.oup.com
Mitochondria are key to energy conversion in virtually all eukaryotes. Intriguingly, despite
billions of years of evolution inside the eukaryote, mitochondria have retained their own …

Assessing the fitness consequences of mitonuclear interactions in natural populations

GE Hill, JC Havird, DB Sloan, RS Burton… - Biological …, 2019 - Wiley Online Library
Metazoans exist only with a continuous and rich supply of chemical energy from oxidative
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …

Selfish mitonuclear conflict

JC Havird, ES Forsythe, AM Williams, JH Werren… - Current Biology, 2019 - cell.com
Mitochondria, a nearly ubiquitous feature of eukaryotes, are derived from an ancient
symbiosis. Despite billions of years of cooperative coevolution—in what is arguably the most …

[HTML][HTML] Redox stress shortens lifespan through suppression of respiratory complex I in flies with mitonuclear incompatibilities

MF Camus, E Rodriguez, V Kotiadis, H Carter… - Experimental …, 2023 - Elsevier
Incompatibilities between mitochondrial and nuclear genes can perturb respiration,
biosynthesis, signaling and gene expression. Here we investigate whether mild mitonuclear …

Variation in mitochondrial DNA affects locomotor activity and sleep in Drosophila melanogaster

L Anderson, MF Camus, KM Monteith, TS Salminen… - Heredity, 2022 - nature.com
Mitochondria are organelles that produce cellular energy in the form of ATP through
oxidative phosphorylation, and this primary function is conserved among many taxa …

Sex-specific effects of mitochondrial haplotype on metabolic rate in Drosophila melanogaster support predictions of the Mother's Curse hypothesis

V Nagarajan-Radha, I Aitkenhead… - … of the Royal …, 2020 - royalsocietypublishing.org
Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the
accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign …

Mitochondrial genetic variation as a potential mediator of intraspecific behavioural diversity

JA Brand, F Garcia-Gonzalez, DK Dowling… - Trends in ecology & …, 2024 - cell.com
Mitochondrial genes play an essential role in energy metabolism. Variation in the
mitochondrial DNA (mtDNA) sequence often exists within species, and this variation can …

[HTML][HTML] Multilevel selection on mitochondrial genomes

MF Camus, AS Dhawanjewar - Current Opinion in Genetics & Development, 2023 - Elsevier
Mitochondria are vital organelles for life in eukaryotes, taking centre stage in the process of
cellular respiration. This process is regulated via a series of finely coordinated obligate …

Challenges and prospects for testing the mother's curse hypothesis

DK Dowling, RE Adrian - Integrative and comparative biology, 2019 - academic.oup.com
Maternal inheritance of mitochondrial DNA (mtDNA) renders selection blind to mutations
whose effects are limited to males. Evolutionary theory predicts this will lead to the …

The reserve/maximum capacity of melatonin's synthetic function for the potential dimorphism of melatonin production and its biological significance in mammals

DX Tan, R Hardeland - Molecules, 2021 - mdpi.com
In this article, we attempt to classify a potential dimorphism of melatonin production. Thus, a
new concept of “reserve or maximum capacity of melatonin synthetic function” is introduced …